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Oral steroids in initial treatment of acute sciatica.Steroids Helpful for Acute Sciatica |
Prednisone Offers Modest Relief in Sciatica | MedPage Today
Prednisone for sciatica.Steroids Helpful or Not Helpful for Acute Sciatica Pain?
I have had CLL for 26 years. I'm not currently being treated, but my white blood count is high. I had heart valve replacement surgery years ago with no complications. I am currently on a tapered course of prednisone as treatment for sciatica pain. I was badly constipated for 2 days, and I still have abdominal cramps. What should I do? Some studies have found that prednisone is effective at treating sciatica. People who were on prednisone needed fewer epidural injections to relieve pain, but the study called the improvement "subtle but statistically significantly"; that is, the improvement was helpful but not all that strong.
So you may not feel the relief you were hoping for from your medication. Prednisone can cause a lot of side effects, including aggression, irritation, and hunger. It doesn't mean that it will cause them in you, but the potential is there. Short-term courses of prednisone are less likely to cause them. If you're looking for other articles that may help you relieve your sciatica pain, these could be helpful:.
You should know: The answer above provides general health information that is not intended to replace medical advice or treatment recommendations from a qualified healthcare professional. What can we help you find?
Pain Management. Is Prednisone Effective in Treating Sciatica? June 6, What to Read Next. Start Survey.
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Some studies have found that prednisone is effective at treating sciatica. People who were on prednisone needed fewer epidural injections to relieve pain, but the study called the improvement "subtle but statistically significantly"; that is, the improvement was helpful but not all that strong. So you may not feel the relief you were hoping for from your medication. Prednisone can cause a lot of side effects, including aggression, irritation, and hunger.
It doesn't mean that it will cause them in you, but the potential is there. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Publications automatically indexed to this study by ClinicalTrials. Oral steroids for acute radiculopathy due to a herniated lumbar disk: a randomized clinical trial.
Back Pain Leg Pain. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Drug: Prednisone Drug: Placebo. Phase 2. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Triple Participant, Care Provider, Investigator.
Study Start Date :. Actual Primary Completion Date :. Patients who received prednisone tended to receive fewer epidural injections for pain. Conclusions: Early administration of oral steroid medication in patients with acute sciatica had no significant effect on most parameters studied. It did, however, lead to slightly more rapid rates of improvement in pain, mental well-being, and disability scores.
Study record managers: refer to the Data Element Definitions if submitting registration or results information. Sciatica is most often caused by a herniated disc in the lumbar region of the back and results from inflammation of the nerve roots as they exit the spine. It is a very common cause of back and leg pain, loss of function, and inability to work. Although sciatica is common, the effectiveness of current treatments is limited.
Epidural steroid injections ESIswhich can reduce inflammation of the nerve roots, are commonly used to decrease sciatica pain and restore normal function in patients.
The exact effectiveness of ESIs, however, is unknown. If inflammation, and not compression, is the main cause of sciatica, it is reasonable to consider giving the steroid orally rather than by injection. If oral steroids prove effective, patients and clinicians will have access to a simple, inexpensive therapy that can be prescribed by primary care physicians without delay. This study will determine the effectiveness of the oral steroid prednisone in decreasing pain and improving function in people with sciatica.
Participants in this study will attend a screening visit at which they will answer questions about their health to determine eligibility, undergo a neurologic exam, and have a plain lower spine x-ray. An MRI of the lower spine will be performed for those who meet clinical eligibility. Participants whose MRI shows that a disc has ruptured in a specific way will be randomly assigned to receive either a day course of prednisone capsules or a day course of placebo capsules.
Participants will take their assigned study medications in addition to their usual pain medications. At Week 3, participants will return for a follow-up visit during which they will answer questions about their pain and general health and wellness.
Participants who are still having considerable pain will be offered an epidural steroid injection ESI as a part of the study. At Week 6, participants will be called at home for a telephone interview and again answer questions about their general health and wellness; this telephone call will last about 20 minutes. If they continue to have considerable pain, they will be offered a second ESI as part of the study.
At Week 12, an interviewer will phone participants to determine if their pain has decreased and whether they have been able to return to their normal activities. The telephone contact will last about 20 minutes. Additional information about their back problems will be obtained from their medical records and from Kaiser Permanente's computerized medical records on their use of health care and medicines for back problems.
At Week 24, participants will attend an evaluation visit at the Spine Clinic to assess their progress and symptoms. At Week 52 1 year from randomizationparticipants will undergo a final telephone interview. Drug: Prednisone For participants who weigh 50 kg or more, the prednisone dose will be 60 mg daily for 5 days, then 40 mg daily for 5 days, and then 20 mg daily for 5 days. For participants who weigh less than 50 kg, the dose will be 40 mg daily for 10 days, and then 20 mg daily for 5 days.
Placebo Comparator: Placebo Participants will receive a day course of placebo capsules. Drug: Placebo Placebo capsules will look the same as the study medication but will not contain active medicine. It is measured on a 0-to scale, with higher numbers indicating greater disability. Secondary Outcome Measures : Pain Numerical Rating Scale [ Time Frame: Baseline, Week 3 follow-up ] Ordinal scale of average level of pain as perceived by the participant over the prior 3 days; measured on a 0-to scale, with higher numbers indicating greater pain.
Pain Numerical Rating Scale [ Time Frame: Baseline, Week 52 follow-up ] Ordinal scale of average level of pain as perceived by the participant over the prior 3 days; measured on a 0-to scale, with higher numbers indicating greater pain. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
For general information, Learn About Clinical Studies. We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U.
Federal Government. Read our disclaimer for details. Results First Posted : April 28, Last Update Posted : April 28, View this study on Beta.
Study Description. Sciatica is a condition that causes a sharp, burning pain in the back, buttock, and leg. The condition is caused by injury to or compression of the sciatic nerve, which is located in the back of the leg. This study will determine the effectiveness of the steroid prednisone in decreasing pain and improving function in people with sciatica.
Detailed Description:. Drug Information available for: Prednisone. FDA Resources. Arms and Interventions. For participants who weigh 50 kg or more, the prednisone dose will be 60 mg daily for 5 days, then 40 mg daily for 5 days, and then 20 mg daily for 5 days. Participants will receive a day course of placebo capsules. Placebo capsules will look the same as the study medication but will not contain active medicine.
Outcome Measures. The Oswestry Disability Index, v2 is a back-pain-specific measure of disability and functional status. Ordinal scale of average level of pain as perceived by the participant over the prior 3 days; measured on a 0-to scale, with higher numbers indicating greater pain.
Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Publications automatically indexed to this study by ClinicalTrials. Oral steroids for acute radiculopathy due to a herniated lumbar disk: a randomized clinical trial. Back Pain Leg Pain. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Drug: Prednisone Drug: Placebo.
Phase 2. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Triple Participant, Care Provider, Investigator. Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :. Experimental: Prednisone Participants will receive a day tapering course of prednisone capsules. R01AR U.
April 29, Key Record Dates.
Objective: Many physicians use prednisone to treat acute sciatica with the hope of speeding recovery. There is little clinical evidence to support this. This study will determine the effectiveness of the steroid prednisone in decreasing pain and improving function in people with sciatica. Researchers examined the impact of oral prednisone on function and pain levels in patients with sciatica from herniated disk. Oral steroid tapers such as the prednisone taper used in the study are commonly used medications in patients with an acute episode of sciatica . Objective: Many physicians use prednisone to treat acute sciatica with the hope of speeding recovery. There is little clinical evidence to support this. Goldberg's group pointed out that, despite conflicting evidence, epidural steroid injections are offered to patients "under the assumption that radicular symptoms are caused by inflammation of the affected lumbar nerve root. There is little clinical evidence to support this practice.Objective: Many physicians use prednisone to treat acute sciatica with the hope of speeding recovery. There is little clinical evidence to support this practice. Our objective was to determine whether early administration of oral prednisone affects parameters related to recovery from acute sciatica.
Patients and investigators were blinded to the drug administered. Follow-up assessment was done weekly for 1 month and then monthly for 5 months. Results: Prednisone and control groups showed no statistically significant differences in physical findings, use of nonsteroidal anti-inflammatory drugs or narcotic medications, or rates of patients returning to work at any time interval studied. Compared with controls, patients who received prednisone had more rapid rates of improvement from baseline in pain, mental well-being, and disability scores.
These changes were subtle but statistically significant. Patients who received prednisone tended to receive fewer epidural injections for pain.
Conclusions: Early administration of oral steroid medication in patients with acute sciatica had no significant effect on most parameters studied.
It did, however, lead to slightly more rapid rates of improvement in pain, mental well-being, and disability scores. The impact of oral steroids on other outcomes is suggested by this study, but its small sample size limited its statistical power.
Abstract Objective: Many physicians use prednisone to treat acute sciatica with the hope of speeding recovery. Substances Glucocorticoids Prednisone.
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